#4343 COMPARISONS OF CLINICAL OUTCOMES BETWEEN HYPERTENSIVE AND NORMOTENSIVE LIVING KIDNEY DONORS: A NATIONWIDE PROSPECTIVE COHORT STUDY

Abstract Background and Aims Living kidney donors with hypertension is potential candidates to solve the imbalance between supply demand for renal transplantation. However, safety of hypertensive donor not sufficiently ensured after nephrectomy there are limited studies, which compare clinical outcomes normotensive donors. Method All data from this study were obtained Korean Organ Transplantation Registry (KOTRY). A total 672 5,134 living included May 2014 December 2020. Primary outcome was occurrence proteinuria development lower function, defined as an estimated glomerular filtration rate (eGFR) less than 60 or 45 ml/min/1.73 m2. Results Compared donors, had eGFR before remained risk below m2 (adjusted HR, 0.87; 95% CI 0.70-1.09; P = 0.226) 1.49; 0.77-2.86; 0.234) significantly increased in multiple adjustment. When comparing decline no significant difference unstandardized β, −0.19; −1.15 – 0.76, 0.691). The incidence increased, it tended increase even 4-5 years. Hypertensive found have more 1.83; 1.13-2.96; 0.014). Conclusion Our indicated that donation donor, while translated into function. continuous careful monitoring should be required nephrectomy.